Press Releases May 29, 2026 06:50 AM

Pharvaris to Present Clinical Data at the EAACI Annual Congress 2026

Pharvaris to Present Promising Phase 3 Clinical Trial Data for Deucrictibant at EAACI 2026

By Priya Menon PHVS

Pharvaris, a Nasdaq-listed biopharmaceutical company, announced the acceptance of multiple abstracts related to its oral bradykinin B2 receptor antagonist, deucrictibant, for presentation at the EAACI Annual Congress 2026. The presentations will showcase positive Phase 3 RAPIDe-3 trial results for on-demand treatment of hereditary angioedema (HAE) attacks, alongside safety and efficacy data for extended-release formulations and long-term prophylactic use. Pharvaris is preparing regulatory submissions and conducting ongoing pivotal studies that could establish new oral treatments for bradykinin-mediated angioedema.

Pharvaris to Present Clinical Data at the EAACI Annual Congress 2026
PHVS

Key Points

  • Pharvaris will present pivotal Phase 3 RAPIDe-3 trial data demonstrating deucrictibant's efficacy as an oral on-demand treatment for hereditary angioedema attacks.
  • Long-term safety and efficacy data for deucrictibant extended-release formulations will also be presented, supporting potential prophylactic uses.
  • These developments could transform the management of bradykinin-mediated angioedema by providing oral therapies with injectable-like efficacy, impacting biopharma and rare disease treatment sectors.

ZUG, Switzerland, May 29, 2026 (GLOBE NEWSWIRE) -- Pharvaris (Nasdaq: PHVS), a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to help address unmet needs of those living with bradykinin-mediated diseases such as hereditary angioedema (HAE) and acquired angioedema due to C1 inhibitor deficiency (AAE-C1INH), today announced the acceptance of one abstract for oral presentation and seven abstracts for flash talk/poster presentation at the European Academy of Allergy and Clinical Immunology (EAACI) Annual Congress 2026, to be held from June 12-15, 2026, in Istanbul, Turkey.

Details of the presentations are as follows:

  • Title: Oral Deucrictibant Immediate-Release Capsule for On-Demand Treatment of Hereditary Angioedema Attacks: End of Progression Results in the Phase 3 RAPIDe-3 Trial
    Presenter: Mauro Cancian, M.D., Ph.D.
    Format: Oral Presentation
    Date, time: Friday, June 12, 2026, 3:00-4:30 p.m. TRT (8:00-9:30 a.m. EDT)
  • Title: Clinical Cardiovascular Safety Assessment of Oral Deucrictibant
    Presenter: Anne Lesage, Ph.D.
    Format: Poster Presentation
    Date, time: Friday, June 12, 2026, 12:00-1:00 p.m. TRT (5:00-6:00 a.m. EDT)
  • Title: A Clinically Validated Kinin Biomarker Assay to Differentiate Bradykinin-Mediated from Mast Cell-Mediated Angioedema
    Presenter: Evangelia Pardali, Ph.D.
    Format: Poster Presentation
    Date, time: Friday, June 12, 2026, 12:00-1:00 p.m. TRT (5:00-6:00 a.m. EDT)
  • Title: Evaluations of Safety Margins and Response to Deucrictibant Extended-Release (XR) Tablet in Combination with Deucrictibant Immediate-Release (IR) Capsule
    Presenter: Anne Lesage, Ph.D.
    Format: Poster Presentation
    Date, time: Saturday, June 13, 2026, 12:00-1:00 p.m. TRT (5:00-6:00 a.m. EDT)
  • Title: Oral Deucrictibant Immediate-Release Capsule for On-Demand Treatment of Hereditary Angioedema Attacks: Results of the Phase 3 RAPIDe-3 Trial
    Presenter: Philip Li, M.D., FRCP
    Format: Poster Presentation
    Date, time: Saturday, June 13, 2026, 12:00-1:00 p.m. TRT (5:00-6:00 a.m. EDT)
  • Title: RAPIDe-3 Patient Voices: Qualitative Insights from the Phase 3 Study of Oral Deucrictibant for On-Demand Treatment of Hereditary Angioedema Attacks
    Presenter: Anna Valerieva, M.D., Ph.D.
    Format: Poster Presentation
    Date, time: Saturday, June 13, 2026, 12:00-1:00 p.m. TRT (5:00-6:00 a.m. EDT)
  • Title: Results of the Phase 2 CHAPTER-1 Open-Label Extension Study on the Long-Term Safety and Efficacy of Oral Deucrictibant for Prophylaxis in Hereditary Angioedema
    Presenter: Markus Magerl, M.D.
    Format: Flash Talk
    Date, time: Saturday, June 13, 2026, 3:00-4:30 p.m. TRT (8:00-9:30 a.m. EDT)
  • Title: CHAPTER-1 Open-Label Extension Study: Long-Term Prophylactic Treatment with Oral Deucrictibant Improved Disease Control and Health-Related Quality of Life in Participants with Hereditary Angioedema
    Presenter: Markus Magerl, M.D.
    Format: Flash Talk
    Date, time: Saturday, June 13, 2026, 3:00-4:30 p.m. TRT (8:00-9:30 a.m. EDT)


The posters and presentation slides will be made available on the Investors section of the Pharvaris website at the beginning of the respective presentations at: ir.pharvaris.com/news-events/events-presentations.

About Pharvaris
Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to help address unmet needs in bradykinin-mediated conditions, including all types of bradykinin-mediated angioedema. Pharvaris’ aspiration is to offer therapies with injectable-like efficacy™, a well-tolerated profile, and the convenience of oral administration to prevent and treat bradykinin-mediated angioedema attacks. By delivering on this aspiration, Pharvaris aims to provide a new standard of care in bradykinin-mediated angioedema. Pharvaris is preparing marketing authorization applications for deucrictibant immediate-release capsule as an on-demand treatment of HAE attacks, and a global pivotal Phase 3 study of deucrictibant extended-release tablet for the prevention of HAE attacks (CHAPTER-3) is ongoing with topline data anticipated in the third quarter of 2026. In addition, CREAATE is an ongoing Phase 3 study of deucrictibant for the prophylactic and on-demand treatment of AAE-C1INH attacks. For more information, visit https://pharvaris.com/.


Risks

  • Regulatory approvals for deucrictibant's marketing authorization are still pending, which poses a timing and outcome uncertainty affecting Pharvaris's commercial prospects.
  • Ongoing Phase 3 studies (CHAPTER-3 and CREAATE) results remain material, and any negative or inconclusive data could delay or impair product launches.
  • There is inherent risk in patient adoption and market competition within the rare disease and allergy treatment markets, which could impact the commercial success of the therapies.

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