Insider Trading June 5, 2026 05:55 PM

Cadrenal Therapeutics CEO Executes Sales Under Pre-Arranged Plan

Quang Pham divests shares as the biotech firm advances CAD-1005 toward Phase 3 trials for heparin-induced thrombocytopenia.

By Caleb Monroe
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CVKD

Quang X. Pham, serving as both Chief Executive Officer and Chairman of Cadrenal Therapeutics, Inc. (NASDAQ: CVKD), has executed a series of stock sales totaling $36,209. These transactions occurred over a three-day period from June 3 to June 5, 2026, with prices ranging between $4.26 and $4.42 per share. The sales were conducted under a Rule 10b5-1 trading arrangement established in September 2025. Following these divestments, Mr. Pham retains direct ownership of 173,224 shares, while an additional 200,000 shares are held indirectly through The PVBQ Living Trust. The company is currently navigating a challenging market environment, with its stock trading near its 52-week low of $4.14 after a 70% decline over the past year. Despite this downturn, recent developments indicate progress in its clinical pipeline, particularly regarding its investigational treatment CAD-1005 for heparin-induced thrombocytopenia (HIT).

Cadrenal Therapeutics CEO Executes Sales Under Pre-Arranged Plan
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Key Points

  • CEO Quang Pham sold shares totaling $36,209 under a pre-arranged trading plan, retaining significant direct and indirect holdings.
  • The company's stock has declined 70% over the past year, trading near its 52-week low of $4.14.
  • Cadrenal Therapeutics advanced CAD-1005 to a Phase 3 trial for heparin-induced thrombocytopenia, following FDA guidance.

Quang X. Pham, the Chief Executive Officer and Chairman of Cadrenal Therapeutics, Inc. (NASDAQ: CVKD), has completed a series of stock sales amounting to $36,209. The divestments were executed over three consecutive days, spanning from June 3 to June 5, 2026. The weighted average prices for these transactions ranged from $4.26 to $4.42 per share.

Mr. Pham conducted these sales under a Rule 10b5-1 trading arrangement, which he initially adopted on September 25, 2025. The specific breakdown of the sales includes the following details:

  • On June 3, 2026, Mr. Pham sold 2,323 shares at a weighted average price of $4.26.
  • On June 4, 2026, he sold an additional 3,898 shares at a weighted average price of $4.41.
  • On June 5, 2026, he sold 2,064 shares at a weighted average price of $4.42.

Following these transactions, Mr. Pham's direct holding in Cadrenal Therapeutics common stock stands at 173,224 shares. Furthermore, he holds an indirect interest in 200,000 shares through The PVBQ Living Trust, where he serves as the trustee.

The company's stock is currently trading near its 52-week low of $4.14. Over the past year, the stock has experienced a significant decline of 70%. Despite this downturn, analysis suggests that the company may be undervalued at current levels, with detailed Fair Value metrics available to subscribers.

In other recent developments, Cadrenal Therapeutics reported a net loss of $3.0 million for the fourth quarter ending December 31, 2025. This represents an improvement from the $4.2 million loss recorded in the same period of 2024. The company has also completed an End-of-Phase 2 meeting with the U.S. Food and Drug Administration regarding its investigational treatment, CAD-1005, for heparin-induced thrombocytopenia (HIT). Cadrenal plans to advance directly to a randomized, blinded, placebo-controlled Phase 3 trial, which will include approximately 120 patients worldwide. The FDA provided guidance on various aspects of the trial, including protocol design, study population, and safety database. This trial is intended to support a projected New Drug Application submission in 2029. The primary endpoint for the study will focus on new or worsening thrombotic events. Cadrenal is currently incorporating FDA feedback into its Phase 3 protocol. These developments mark significant progress in the company's efforts to address HIT.

Cadrenal Therapeutics Inc.

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Risks

  • The stock's 70% decline over the past year and trading near its 52-week low indicate significant market volatility and potential valuation challenges.
  • The company reported a net loss of $3.0 million for Q4 2025, highlighting ongoing financial pressures despite improvements from the prior year.
  • The Phase 3 trial for CAD-1005 involves approximately 120 patients and focuses on thrombotic events, introducing clinical trial execution risks.

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