Press Releases July 28, 2026 08:00 AM

Nuwellis Expands Pediatric Footprint with First Aquadex SmartFlow® Installations in Wisconsin

Nuwellis expands pediatric critical care presence with first Aquadex SmartFlow installations in Wisconsin, targeting growth in pediatric fluid management therapy.

By Jordan Park
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Nuwellis, Inc. announced the installation of its Aquadex SmartFlow systems at a leading pediatric hospital in Wisconsin, marking its entry into a new pediatric market and expanding its footprint in critical care. The company targets growth by developing clinical protocols for Aquadex therapy, which aids precise fluid removal in critically ill children. Anticipated FDA submission aims to expand Aquadex use to smaller pediatric patients by end of 2026, supporting broader adoption and strengthening market leadership.

Nuwellis Expands Pediatric Footprint with First Aquadex SmartFlow® Installations in Wisconsin
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Key Points

  • Nuwellis installed its first Aquadex SmartFlow systems in Wisconsin at a major pediatric healthcare institution, expanding its pediatric footprint.
  • The company is developing clinical pathways integrating Aquadex therapy for critically ill pediatric patients with fluid overload unresponsive to diuretics.
  • A planned FDA 510(k) submission by end of 2026 aims to expand Aquadex label to include pediatric patients weighing 5 kilograms and above.
  • Impacted sectors include medical technology, healthcare services focused on critical and pediatric care, and cardiorenal treatment markets.

MINNEAPOLIS, July 28, 2026 (GLOBE NEWSWIRE) -- Nuwellis, Inc. (Nasdaq: NUWE), a medical technology company committed to delivering solutions for patients with cardiorenal conditions, announces its expansion into Wisconsin with the installation of its first Aquadex SmartFlow® systems at a leading pediatric healthcare institution. The installation further expands the Company's growing presence in pediatric critical care at one of the region's premier academic medical centers.

"Establishing our first pediatric program in Wisconsin reflects the continued momentum of our pediatric growth and increasing clinical adoption of our Aquadex therapy and entry into a key market facilitating continued growth in our largest customer category," said Nuwellis’ CEO Mike McCormick. "Leading pediatric hospitals continue to recognize the importance of precise fluid management for critically ill children. This collaboration provides an opportunity to establish clinical protocols and workflows that can support broader utilization of Aquadex therapy over time while strengthening our presence in another important pediatric market."

The new system installations will support the development of clinical pathways and integrate Aquadex therapy into the hospital's pediatric care program. Nuwellis continues to prioritize expansion within pediatric and critical care settings, where clinicians are increasingly adopting Aquadex therapy to provide controlled, predictable fluid removal for patients suffering from fluid overload. Pediatric programs remain a strategic growth opportunity as the Company works to broaden access to the therapy and further strengthen its leadership position in the category.

The Aquadex SmartFlow System is designed to provide precise ultrafiltration therapy for adult and pediatric patients weighing 20 kilograms and above who are suffering from fluid overload and are unresponsive to medical management, including diuretics. Nuwellis recently completed a pre-submission meeting with the U.S. Food and Drug Administration (FDA) regarding a proposed expansion of the Aquadex label to support pediatric patients weighing 5 kilograms and above. The Company anticipates a 510(k) submission to the FDA for the expanded label by the end of 2026.

About Aquadex
The Aquadex SmartFlow System is currently indicated for the continuous ultrafiltration therapy for temporary (up to 8 hours) or extended (longer than 8 hours in patients who require hospitalization) use in adult and pediatric patients weighing 20 kilograms or more whose fluid overload is unresponsive to medical management, including diuretics. All treatments must be administered by a healthcare provider, within an outpatient or inpatient clinical setting, under physician prescription, both of whom having received training in extracorporeal therapies.

About Nuwellis
Nuwellis, Inc. (Nasdaq: NUWE) is a medical technology company committed to delivering solutions for patients with cardiorenal conditions. The Company develops solutions designed to support patient care through monitoring, therapy, and data-informed clinical decision-making across acute and chronic care settings. Nuwellis’ portfolio includes commercially available and development-stage technologies addressing complex cardiorenal conditions, with a focus on safety, precision, and scalability across patient populations. For more information, visit www.nuwellis.com.

Forward-Looking Statements
Certain statements in this release may be considered forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including without limitation, statements regarding the new market opportunities and anticipated growth in 2026 and beyond. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this release, including, without limitation, those risks associated with our ability to execute on our commercialization strategy, the possibility that we may be unable to raise sufficient funds necessary for our anticipated operations, our post-market clinical data collection activities, benefits of our products to patients, our expectations with respect to product development and commercialization efforts, our ability to increase market and physician acceptance of our products, potentially competitive product offerings, intellectual property protection, our ability to integrate acquired businesses, our expectations regarding anticipated synergies with and benefits from acquired businesses, and other risks and uncertainties described in our filings with the SEC. Forward-looking statements speak only as of the date when made. Nuwellis does not assume any obligation to publicly update or revise any forward-looking statements, whether due to new information, future events or otherwise.

For further information, please contact:

Investor Relations:
CORE IR
[email protected]

Media Contact:
CORE PR
[email protected]


Risks

  • Uncertainties around successful execution of commercialization strategy and achieving anticipated growth.
  • Potential challenges in FDA approval process for expanded pediatric labeling, which could delay market access.
  • Competitive pressures from alternative therapies and advancing technologies in critical care and fluid management sectors, affecting market share and adoption rates.

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