Press Releases April 16, 2026 08:50 AM

Palisade Bio Announces Abstract Selected for Poster Presentation at Digestive Disease Week (DDW) 2026

Palisade Bio to Present Promising Phase 1 Data on PALI-2108 for Ulcerative Colitis at DDW 2026

By Jordan Park PALI
Palisade Bio Announces Abstract Selected for Poster Presentation at Digestive Disease Week (DDW) 2026
PALI

Palisade Bio announced that data from its lead candidate, PALI-2108, a novel oral PDE4 inhibitor prodrug targeting the ileum and colon, will be presented at Digestive Disease Week 2026. The Phase 1 study data demonstrates rapid clinical, histologic, and biomarker improvements in ulcerative colitis patients. The company is progressing towards a Phase 2 clinical study to further evaluate efficacy and safety over 12 weeks, including remission maintenance.

Key Points

  • Palisade Bio's lead program, PALI-2108, showed promising Phase 1 results for ulcerative colitis with rapid improvements in clinical and biomarker endpoints.
  • The company will present this data at Digestive Disease Week 2026, a prominent gastroenterology conference, underscoring its engagement with leading IBD experts.
  • Advancement towards a Phase 2 study aimed at evaluating longer-term clinical remission and response over 12 weeks, including maintenance of remission.
  • Sectors impacted include biotech, pharmaceutical R&D focused on inflammatory bowel disease, and gastroenterology therapeutics markets.

Poster presentation scheduled for Tuesday, May 5th at 12:30 PM CDT

Denver, CO, April 16, 2026 (GLOBE NEWSWIRE) -- Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”), a clinical-stage biopharmaceutical company developing next-generation, once-daily, oral PDE4 inhibitor prodrugs designed for targeted delivery to the terminal ileum and colon, today announced that data from its lead program, PALI-2108, has been selected for poster presentation at Digestive Disease Week® (DDW) 2026, taking place May 2–5, 2026 in Chicago.

The Company will be in attendance alongside members of its Clinical Advisory Board (CAB), further reinforcing its engagement with leading experts in inflammatory bowel disease as it advances PALI-2108 toward the clinic.

Poster Presentation details are as follows:
Session Type: Abstract Poster
Session Title: Mechanisms of IBD Therapeutics
Title: Gut-Targeted PDE4 Inhibition with PALI-2108 Demonstrates Rapid Clinical, Histologic and Biomarker Improvement in Ulcerative Colitis: Translational Findings from a Phase 1 Study
Session Date & Time: May 5, 2026 from 12:30 PM to 1:30 PM CDT
Location: Poster Hall, Level 3, Hall F2 (McCormick Place)

Management will be available to participate in one-on-one meetings with qualified members of the investor community.

Digestive Disease Week is a leading forum for experts in the field of gastroenterology bringing together clinicians, researchers, and pharmaceutical leaders to discuss the latest advancements in treating digestive diseases. For more information about Digestive Disease Week please visit the conference website.

About Palisade Bio

Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”) is a clinical-stage biopharmaceutical company advancing next-generation oral PDE4 inhibitor prodrugs designed for gut-targeted delivery and selective bioactivation in the ileum and colon, with the goal to improve pharmacology, tolerability and convenience for patients with inflammatory and fibrotic diseases. Through its differentiated prodrug platform and precision pharmacology strategy, Palisade Bio is committed to transforming proven PDE4 biology into better, safer oral therapies.

The Company’s lead program, PALI-2108, is a once-daily oral PDE4 inhibitor prodrug designed to initiate localized PDE4 inhibition at sites of disease while enabling systemic distribution of the active drug.

Palisade Bio is now advancing towards a Phase 2 clinical study in UC designed to evaluate clinical remission, response and pharmacodynamic biomarkers over 12 weeks, with an extension phase assessing maintenance of remission. For more information, please go to www.palisadebio.com.

Investor Relations Contact

JTC Team, LLC
Jenene Thomas
908-824-0775
[email protected]


Risks

  • Clinical development risk inherent to advancing from Phase 1 to Phase 2 and beyond, with the possibility that further trials may not replicate early positive findings.
  • Regulatory risk including approval hurdles related to new drug applications for PDE4 inhibitor prodrugs targeting gut diseases.
  • Market adoption and competitive risk from other established or emerging therapies for ulcerative colitis and inflammatory bowel diseases, affecting commercialization potential.

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