Press Releases April 28, 2026 07:30 AM

NorthStrive Biosciences Files New U.S. Patent Application for EL-22 Targeting Muscle Preservation in Humans

NorthStrive Biosciences, a PMGC Holdings subsidiary, files new US patent application for EL-22 targeting muscle preservation in humans

By Leila Farooq ELAB
NorthStrive Biosciences Files New U.S. Patent Application for EL-22 Targeting Muscle Preservation in Humans
ELAB

NorthStrive Biosciences Inc., a subsidiary of PMGC Holdings Inc. (Nasdaq: ELAB), announced the filing of a new US patent application covering the development of EL-22, a myostatin-engineered probiotic technology, for pharmaceutical use targeting muscle loss conditions in humans. The patent includes protection for specific dosing regimens and formulations for treating muscle-wasting diseases such as sarcopenia, muscle disuse atrophy, and neurological disorders. This move strengthens the company's intellectual property portfolio and broadens its focus on muscle health therapeutics in pharmaceutical markets.

Key Points

  • NorthStrive filed a new US patent application for EL-22 targeting muscle loss treatment in humans, expanding its intellectual property portfolio.
  • EL-22 is a myostatin-engineered probiotic technology designed for muscle preservation and growth, including applications for patients on weight loss treatments.
  • The patent filing covers various muscle-wasting conditions including sarcopenia and neurological disorder-related muscle loss, highlighting potential pharmaceutical and adjacent market opportunities.

NEWPORT BEACH, Calif., April 28, 2026 (GLOBE NEWSWIRE) -- NorthStrive Biosciences Inc. (“NorthStrive” or the “Company”), a wholly owned subsidiary of PMGC Holdings Inc. (Nasdaq: ELAB) (“PMGC”), today announced the filing of a new U.S. patent application expanding its proprietary EL-22, a myostatin-engineered probiotic technology, into human pharmaceutical applications.

The patent application (U.S. Application No. 19/655,160) covers the development of a formulated pharmaceutical product utilizing EL-22 for use in human patients suffering from muscle loss. The application includes protection for specific dosing regimens and formulations targeting a broad range of muscle-wasting conditions.

The proposed therapeutic use of EL-22 is intended to address muscle loss associated with conditions such as sarcopenia, muscle disuse atrophy, and certain neurological disorders. This filing expands NorthStrive’s intellectual property strategy, building on prior applications focused on muscle preservation and growth.

NorthStrive’s lead asset, EL-22, leverages a myostatin engineered probiotic approach designed to support muscle preservation and growth, including in patients undergoing weight loss treatments such as GLP-1 receptor agonists.

This newly filed patent application is intended to strengthen NorthStrive’s expanding intellectual property portfolio and reflects the Company’s focus on muscle health therapeutics across pharmaceutical and adjacent markets.

About NorthStrive Biosciences Inc.
NorthStrive Biosciences Inc., a PMGC Holdings Inc. company, is a biopharmaceutical company focused on the development and acquisition of cutting-edge therapeutic technologies. The Company is advancing a pipeline of assets targeting muscle preservation, metabolic health, and related conditions.

About PMGC Holdings Inc.
PMGC Holdings Inc. is a diversified holding company that manages and grows its portfolio through strategic acquisitions, investments, and development across multiple industries. PMGC is focused on building long-term shareholder value through operational excellence and disciplined capital allocation. For more information, please visit https://www.pmgcholdings.com.

Forward-Looking Statements

Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Words such as “believes,” “expects,” “plans,” “potential,” “would” and “future” or similar expressions such as “look forward” are intended to identify forward-looking statements. Forward-looking statements are made as of the date of this press release and are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy, activities of regulators and future regulations and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Although PMGC believes that the expectations expressed in these forward-looking statements are reasonable, it cannot assure you that such expectations will turn out to be correct, and PMGC cautions investors that actual results may differ materially from the anticipated results. Therefore, you should not rely on any of these forward-looking statements. These and other risks are described more fully in PMGC’s filings with the United States Securities and Exchange Commission (“SEC”), including the “Risk Factors” section of PMGC’s Annual Report on Form 10-K for the year ended December 31, 2025, filed with the SEC on March 30, 2026, and its other documents subsequently filed with or furnished to the SEC. Investors and security holders are urged to read these documents free of charge on the SEC’s web site at www.sec.gov. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except to the extent required by law, PMGC undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

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Risks

  • Patent approval is uncertain and the technology may face regulatory hurdles before commercialization, impacting timelines and market potential.
  • Market adoption risks exist for new biotech therapies for muscle preservation, including competition and acceptance by medical providers.
  • Commercial success depends on future clinical trial outcomes and reimbursement scenarios, creating financial and operational uncertainties.

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