Press Releases April 27, 2026 08:30 AM

Erasca to Host Conference Call and Webcast to Discuss Preliminary Phase 1 Dose Escalation Data for Potentially Best-in-Class Pan-RAS Molecular Glue ERAS-0015

Erasca to Present Preliminary Phase 1 Data on ERAS-0015 Targeting RAS-Mutant Solid Tumors

By Sofia Navarro ERAS
Erasca to Host Conference Call and Webcast to Discuss Preliminary Phase 1 Dose Escalation Data for Potentially Best-in-Class Pan-RAS Molecular Glue ERAS-0015
ERAS

Erasca, Inc., a clinical-stage precision oncology company, announced it will hold a conference call to discuss preliminary Phase 1 dose escalation data for its oral pan-RAS molecular glue ERAS-0015. The early data shows favorable safety, tolerability, and encouraging partial responses in patients with various RAS-mutant solid tumors, supporting its potential as a best-in-class RAS inhibitor. The presentation underscores Erasca's progress in developing therapies targeting RAS/MAPK pathway-driven cancers.

Key Points

  • Erasca presented early Phase 1 data indicating ERAS-0015 has a favorable safety and tolerability profile in RAS-mutant solid tumors.
  • Preliminary efficacy data includes confirmed and unconfirmed partial tumor responses at low doses (8 mg QD) across multiple tumor types and RAS mutations.
  • ERAS-0015 aims to inhibit both mutant and wildtype RAS variants, potentially overcoming resistance seen with mutant-selective inhibitors.

SAN DIEGO, April 27, 2026 (GLOBE NEWSWIRE) -- Erasca, Inc. (Nasdaq: ERAS), a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers, today announced that the Company will host a conference call and webcast to discuss preliminary Phase 1 dose escalation data for its potentially best-in-class pan-RAS molecular glue ERAS-0015 in patients with RAS-mutant solid tumors today, Monday, April 27, 2026, at 4:30 pm ET.

Conference Call and Webcast Information
Erasca will hold a conference call and webcast Monday, April 27, 2026, at 4:30 pm ET. The webcast link for the conference call is here. The dial-in number is 1-877-407-3982 (U.S./Canada) or 1-201-493-6780 (international) or click the Call me™ Link. The live webcast and replay may be accessed by visiting Erasca’s website at Erasca.com/events.

About ERAS-0015
ERAS-0015 is an investigational, oral, highly potent pan-RAS molecular glue designed to inhibit RAS signaling with a potential best-in-class profile. Erasca is evaluating ERAS-0015 in the AURORAS-1 Phase 1 trial in patients with RAS-mutant solid tumors. Early dose escalation data in AURORAS-1 demonstrated favorable safety and tolerability results, well-behaved, linear PK, and confirmed and unconfirmed partial responses in multiple patients across multiple tumor types with different RAS mutations, including confirmed and unconfirmed partial responses at doses as low as 8 mg once daily (QD). ERAS-0015 is also designed to prevent resistance against mutant-selective inhibitors through inhibition of RAS wildtype variants. In addition, ERAS-0015 has demonstrated favorable absorption, distribution, metabolism, and excretion (ADME) and pharmacokinetic (PK) properties in multiple animal species. 

About Erasca
At Erasca, our name is our mission: To erase cancer. We are a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers. Our company was co-founded by leading pioneers in precision oncology and RAS targeting to create novel therapies and combination regimens designed to comprehensively shut down the RAS/MAPK pathway for the treatment of patients with cancer. We believe our team’s capabilities and experience, further guided by our scientific advisory board which includes the world’s leading experts in the RAS/MAPK pathway, uniquely position us to achieve our bold mission of erasing cancer.

Contact:
Joyce Allaire
LifeSci Advisors, LLC
[email protected]

Source: Erasca, Inc.


Risks

  • Preliminary Phase 1 data is early and limited; further clinical development is needed to confirm efficacy and safety.
  • Potential challenges in demonstrating superiority or differentiation over existing RAS-targeted therapies and combination regimens.
  • Uncertainties related to regulatory approval timelines and commercial viability in a competitive oncology market.

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