Press Releases September 30, 2026 04:01 PM

Monte Rosa Therapeutics to Present Results of MRT-8102 GFORCE-1 Phase 1 Study in Subjects with Elevated Cardiovascular Disease Risk

Monte Rosa Therapeutics to present promising Phase 1 data on MRT-8102 targeting cardiovascular disease risk

By Caleb Monroe
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GLUE

Monte Rosa Therapeutics, a clinical-stage biotech company specializing in molecular glue degrader medicines, will present results from its Phase 1 GFORCE-1 study of MRT-8102 in subjects with elevated cardiovascular disease risk. The data showcase safety and activity across multiple doses over four weeks, highlighting modulation of key pathogenic drivers of atherosclerotic cardiovascular disease. The presentation will be webcast on October 1, 2026.

Monte Rosa Therapeutics to Present Results of MRT-8102 GFORCE-1 Phase 1 Study in Subjects with Elevated Cardiovascular Disease Risk
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Key Points

  • Monte Rosa is advancing a novel molecular glue degrader, MRT-8102, aimed at cardiovascular disease, marking progress in targeted therapies for ASCVD.
  • The Phase 1 study evaluated safety and activity at multiple dose levels over a month, showing promising modulation of atherosclerosis drivers.
  • The company uses an AI-guided discovery platform (QuEEN™) to develop highly selective MGDs, with a pipeline spanning autoimmune, inflammatory diseases, and oncology.
  • Sectors impacted include biotechnology, pharmaceuticals, and healthcare, especially cardiovascular and inflammation-related therapies.

BOSTON, Sept. 30, 2026 (GLOBE NEWSWIRE) -- Monte Rosa Therapeutics, Inc. (Nasdaq: GLUE), a clinical-stage biotechnology company developing novel molecular glue degrader (MGD)-based medicines, today announced that management will host a live conference call and webcast on Thursday, October 1, at 8:00 a.m. ET. The webcast presentation will review clinical results from the GFORCE-1 Phase 1 study of the NEK7-directed MGD MRT-8102 in subjects with elevated cardiovascular disease (CVD) risk. The presentation will include safety and activity data for MRT-8102 across multiple dose levels following 4 weeks of treatment and will showcase pioneering data on the modulation of multiple pathogenic drivers of atherosclerotic cardiovascular disease (ASCVD) by MRT-8102.

A webcast of the presentation will be accessible via the “Events & Presentations” section of Monte Rosa’s website at ir.monterosatx.com. Registration for the conference call is available at the following link. An archived version of the webcast will be made available for 30 days following the presentation.

About Monte Rosa
Monte Rosa Therapeutics is a clinical-stage biotechnology company developing highly selective molecular glue degrader (MGD) medicines for patients living with serious diseases. MGDs are small molecule protein degraders that have the potential to treat many diseases that other modalities, including other degraders, cannot. Monte Rosa’s QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI-guided chemistry, diverse chemical libraries, structural biology, and proteomics to rationally design MGDs with unprecedented selectivity. Monte Rosa has developed the industry’s leading pipeline of first-in-class and only-in-class MGDs, spanning autoimmune and inflammatory diseases, oncology, and beyond, with three programs in the clinic. Monte Rosa has ongoing collaborations with leading pharmaceutical companies in the areas of immunology, oncology, and neurology. For more information, visit www.monterosatx.com.

Investors
Andrew Funderburk
[email protected]

Media
Cory Tromblee, Scient PR
[email protected]


Risks

  • The Phase 1 data, while promising, are early-stage; efficacy and safety still need confirmation in later clinical trials, posing clinical development risk.
  • Translating modulation of pathogenic drivers into tangible clinical benefit remains uncertain, affecting regulatory approval and commercialization.
  • Competition and scientific challenges in MGD development and cardiovascular therapeutics may impact the development timeline and market positioning.

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