Stock Markets March 24, 2026

Immunic Shares Climb After Guggenheim Starts Coverage with Buy Rating

Analyst points to Phase II data and favorable safety profile for vidofludimus calcium; Phase III timelines and peak sales assumptions outlined

By Avery Klein IMUX
Immunic Shares Climb After Guggenheim Starts Coverage with Buy Rating
IMUX

Immunic Inc. (NASDAQ:IMUX) shares rose 7.7% after Guggenheim initiated coverage with a Buy rating and a $7.00 price target. The analyst cited Phase II evidence in both relapsing and progressive multiple sclerosis, a placebo-like safety profile, and projected Phase III readouts and peak sales assumptions for the company’s oral candidate vidofludimus calcium.

Key Points

  • Guggenheim initiated coverage of Immunic with a Buy rating and a $7.00 price target, prompting a 7.7% share increase.
  • Vidofludimus calcium has Phase II data in relapsing MS (268 patients) and progressive MS (467 patients) showing reduced relapse risk and disability control, with a placebo-like safety profile.
  • Guggenheim projects positive Phase III ENSURE topline data for relapsing MS by end of 2026 (about 1,100 patients per study) and a primary progressive MS Phase III readout around 2030; peak sales estimates are ~$1B for relapsing MS (75% POS) and ~$2B for primary progressive MS (60% POS).

Immunic Inc. (NASDAQ:IMUX) stock rallied 7.7% on Tuesday following the publication of new coverage from Guggenheim in which analyst Yatin Suneja assigned a Buy rating and set a $7.00 price target.

Suneja’s initiation centers on vidofludimus calcium, an oral therapy being developed to treat multiple sclerosis (MS). The program is intended to address both relapse-associated worsening and progression independent of relapse activity, spanning relapsing and progressive forms of MS.

The analyst referenced two Phase II trials that underpin the program: one in relapsing MS enrolling 268 patients and another in progressive MS with 467 patients. According to the initiation note, those studies demonstrated reduced relapse risk and control of disability. Suneja also emphasized the candidate’s safety profile, reporting that vidofludimus calcium showed a placebo-like safety signal without observed liver toxicity, increased infections, or the need for monitoring burdens that can accompany some MS therapies.

On development timing, Guggenheim expects positive topline Phase III data from the ENSURE program in relapsing MS by the end of 2026. The ENSURE studies are projected to include roughly 1,100 patients per study. A separate Phase III readout for primary progressive MS is anticipated around 2030, according to the analyst’s timeline.

In his financial modeling, Suneja estimated peak worldwide sales of about $1 billion for vidofludimus calcium in relapsing MS, assigning a 75% probability of success to that indication. For primary progressive MS, peak global sales were estimated at roughly $2 billion with a 60% probability of success. Immunic’s fully diluted market capitalization is reported to be about $800 million.

The analyst’s initiation combines clinical readouts, a stated safety profile, and commercial assumptions to support the Buy rating and the $7.00 target. Investors should note the timelines cited for Phase III data and the probability-weighted sales assumptions used in the valuation framework.


Market reaction: Shares rose 7.7% on the news.

Risks

  • Clinical and regulatory timelines - Phase III readouts are projected for 2026 (relapsing MS) and around 2030 (primary progressive MS), creating timing risk for investors and biotech sector participants.
  • Probability of success assumptions - Guggenheim’s valuation relies on assigned probabilities (75% for relapsing MS, 60% for primary progressive MS), which introduce uncertainty to peak sales expectations and company valuation.
  • Market capitalization and valuation sensitivity - Immunic’s reported fully diluted market capitalization of approximately $800 million could be sensitive to clinical readouts and commercial assumptions, affecting investor returns in the biotech and pharmaceutical sectors.

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