Insider Trading March 30, 2026

Xilio Therapeutics Director Adds 5,000 Shares in March Transaction

Director Shannon James Samuel boosts direct stake as company advances financing and clinical milestones

By Maya Rios XLO
Xilio Therapeutics Director Adds 5,000 Shares in March Transaction
XLO

Xilio Therapeutics director Shannon James Samuel purchased 5,000 shares of common stock on March 26, 2026, for a total of $43,949 at a reported price of $8.79 per share. The SEC filing notes transaction prices ranged from $8.6758 to $9.2499. After the purchase, Samuel directly owns 10,000 shares. The transaction occurs while XLO trades at $8.23 and amid recent financing, clinical development updates, and a planned reverse stock split.

Key Points

  • Director Shannon James Samuel purchased 5,000 Xilio Therapeutics shares on March 26, 2026, spending $43,949 at a reported $8.79 per share, with executed prices ranging from $8.6758 to $9.2499.
  • After the transaction Samuel directly owns 10,000 Xilio shares; the company trades at $8.23 and has a market cap of $48 million, with an analyst price target of $20.
  • Xilio recently received $35.8 million in gross proceeds from Series B warrant exercises, plans an IND submission for XTX501 by mid-2026 and a Phase 1 trial in the latter half of 2026 pending FDA clearance, and will implement a 1-for-14 reverse stock split at 5:00 p.m. Eastern Time on Friday.

Transaction details

According to a disclosure filed with the SEC, Shannon James Samuel, a director at Xilio Therapeutics (NASDAQ: XLO), bought 5,000 shares of the company’s common stock on March 26, 2026. The filing records the aggregate cost of the purchase as $43,949 and lists a per-share price of $8.79. A footnote in the filing specifies that the executed prices for the shares ranged between $8.6758 and $9.2499. Following the transaction, Samuel directly holds 10,000 shares of Xilio Therapeutics common stock.

Market context

The director’s acquisition was executed while XLO’s trading price was $8.23, modestly below the price Samuel paid. The company’s market capitalization is $48 million. Analyst coverage cited in the filing includes a price target of $20. The filing also references InvestingPro, which reports that Xilio has more cash on its balance sheet than debt but is rapidly burning through cash. The InvestingPro note indicates that five additional ProTips and more financial metrics are available on that platform.

Recent corporate financing and clinical updates

Xilio reported receiving $35.8 million in gross proceeds from the exercise of Series B warrants. The exercise featured full participation from investors identified in the filing as Coastlands Capital, Frazier Life Sciences, and Gilead Sciences, Inc. The warrant exercise follows a follow-on public offering the company completed in June 2025.

The company has outlined regulatory and clinical milestones for its development pipeline. Xilio plans to submit an investigational new drug application for its candidate XTX501 by mid-2026. Contingent on regulatory clearance, the firm expects a Phase 1 clinical trial for XTX501 to begin in the second half of 2026. Separately, Xilio intends to present data on its experimental therapy XTX601 at the upcoming American Association for Cancer Research Annual Meeting.

Corporate action

Shareholders approved a 1-for-14 reverse stock split of Xilio’s common stock at a special meeting. The company will implement the reverse split effective at 5:00 p.m. Eastern Time on Friday, as noted in its disclosure.


What this means in this report

The disclosure documents the director-level purchase and provides recent corporate-financing and development milestones as reported by the company. All transaction pricing ranges, ownership totals, financing amounts, investor participants, timetable targets for regulatory filings and trials, and the effective timing of the reverse split are taken from the company’s disclosures and related reporting cited in the filing.

Risks

  • Cash burn - The company reportedly has more cash than debt but is rapidly using cash, which could affect its ability to fund operations and trials; this impacts the biotech and capital markets sectors.
  • Regulatory uncertainty - The commencement of the Phase 1 trial for XTX501 is subject to FDA clearance, introducing timing and approval risk for the clinical development program and the healthcare sector.
  • Market mechanics - The planned 1-for-14 reverse stock split will alter share structure and may affect liquidity and investor perceptions in the equity markets.

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