Insider Trading March 18, 2026

Opus Genetics CSO Sells Shares to Cover RSU Tax Withholding; Company Posts Early Positive Trial Signal

Jayagopal Ashwath disposed of 3,719 Opus Genetics shares while the company advances multiple gene therapy programs and a regulatory review for a presbyopia treatment

By Avery Klein IRD
Opus Genetics CSO Sells Shares to Cover RSU Tax Withholding; Company Posts Early Positive Trial Signal
IRD

Opus Genetics Chief Scientific & Development Officer Jayagopal Ashwath sold 3,719 shares on March 16, 2026, to satisfy tax withholding tied to vesting restricted stock units. The transaction, executed at a weighted average price of $5.1213 per share, left Ashwath with 516,775 directly held shares. The company also reported early, favorable safety data from a Phase 1/2 BEST1 gene therapy participant and received FDA acceptance of a supplemental NDA for a presbyopia treatment, among other corporate developments.

Key Points

  • Opus Genetics CSO Jayagopal Ashwath sold 3,719 shares on March 16, 2026, at a weighted average price of $5.1213, totaling $19,046; price range was $5.11 to $5.1301.
  • The sale was executed solely to satisfy tax withholding for vested restricted stock units and was not discretionary; Ashwath now directly holds 516,775 shares.
  • Opus Genetics reported early positive safety data from the first participant in its Phase 1/2 OPGx-BEST1 trial and received FDA acceptance of a supplemental NDA for a presbyopia treatment with an October 17, 2026 review decision date. The company also raised $25 million in a private placement with major participation from Adage Capital Management and plans a clinical trial in Abu Dhabi for a MERTK-related retinitis pigmentosa therapy.

Opus Genetics, Inc. (NASDAQ: IRD) disclosed a non-discretionary stock sale by its Chief Scientific & Development Officer, Jayagopal Ashwath, in a Form 4 filed with the Securities and Exchange Commission. The filing shows Ashwath sold 3,719 shares of common stock on March 16, 2026, at a weighted average price of $5.1213 per share, resulting in proceeds of $19,046. The per-share prices in the transaction ranged from $5.11 to $5.1301.

Following the sale, Ashwath continues to directly hold 516,775 shares of Opus Genetics common stock. The filing specifies that the disposition was executed to cover tax withholding obligations associated with vested restricted stock units and was not a discretionary trade by the executive.


Company program updates

Opus Genetics provided a string of operational updates alongside the insider transaction disclosure. Early data from the company’s Phase 1/2 trial of the OPGx-BEST1 gene therapy for BEST1-related retinal diseases showed that the trial’s first participant experienced no ocular inflammation or treatment-related adverse events at the three-month post-treatment check.

Regulatory activity also advanced: the U.S. Food and Drug Administration accepted Opus Genetics’ supplemental New Drug Application for a presbyopia treatment and set a target review decision date of October 17, 2026.

On the financing front, Opus Genetics raised $25 million in a private placement of Series B Non-Voting Convertible Preferred Stock, with substantial participation from Adage Capital Management. The company indicated the proceeds are intended to support its ongoing gene therapy initiatives.

Operational plans include initiating a clinical trial in Abu Dhabi to assess a gene therapy for MERTK-related retinitis pigmentosa.


Analyst view

Craig-Hallum reiterated a Buy rating on Opus Genetics and maintained a $9.00 price target, citing potential upside tied to the company’s progressing gene therapy programs.

Each of the updates above was disclosed by the company in public filings and statements. The insider sale was explicitly described as a tax-withholding related disposition rather than a discretionary sale by the officer.

Risks

  • Early clinical data referenced are limited to the first participant at a three-month follow-up, leaving broader safety and efficacy outcomes uncertain - impacts the biotech and healthcare sectors.
  • The FDA review for the supplemental NDA has a decision date of October 17, 2026, and the final regulatory outcome is not provided - impacts regulatory risk for the company and investors.
  • While Opus Genetics raised $25 million in a private placement to support gene therapy programs, the adequacy and future availability of financing for ongoing development are not addressed in detail - relevant to corporate finance and biotech capital markets.

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