Insider Trading January 21, 2026

Olema Pharmaceuticals Director Sells $268,800 in Shares Amid Rising Stock Valuation

Cyrus Harmon divests 10,000 shares as multiple firms affirm confident outlook on Olema's breast cancer drug developments

By Maya Rios OLMA
Olema Pharmaceuticals Director Sells $268,800 in Shares Amid Rising Stock Valuation
OLMA

Olema Pharmaceuticals director Cyrus Harmon completed a sale of 10,000 shares on January 20, 2026, generating proceeds of $268,800 at an average share price of $26.88. This move occurs within the context of Olema's significant stock appreciation over the past year and elevated valuation. Several investment firms recently reiterated bullish ratings and increased price targets on Olema, driven by positive clinical trial data and promising drug candidates in the breast cancer treatment space.

Key Points

  • Cyrus Harmon, Olema Pharmaceuticals director, sold 10,000 shares at an average price of $26.88, totaling $268,800 in proceeds.
  • Olema stock has experienced a substantial increase, rising over 360% in the past year, currently trading above its Fair Value with strong buy analyst consensus.
  • Multiple investment firms, including Piper Sandler, UBS, H.C. Wainwright, Goldman Sachs, and Jefferies, have issued bullish ratings and increased price targets on Olema, reflecting optimism around its late-stage breast cancer drug candidate palazestrant.
Director Cyrus Harmon, who holds a directorship at Olema Pharmaceuticals, Inc. (NASDAQ: OLMA), initiated the sale of 10,000 shares of the company's common stock on January 20, 2026, according to a recent SEC Form 4 filing. The shares were disposed of at a weighted average price of $26.88 each, with individual trade prices varying between $26.85 and $26.96. This transaction resulted in gross proceeds totaling approximately $268,800.

This share sale comes against the backdrop of a significant price rally for OLMA stock, which has surged by 362.85% over the preceding 12 months. Current market data from InvestingPro positions the stock above its estimated Fair Value, and analysts maintain a consensus rating of strong buy.

Following the sale, Cyrus Harmon continues to maintain substantial ownership stakes in Olema Pharmaceuticals. His direct holdings amount to 727,770 shares, and he also possesses an indirect interest in 117,028 shares through his role as manager of Harmon Family Investors LLC.

The company itself holds a market capitalization valued at $2.06 billion and has exhibited notable price volatility, achieving a 479.07% return over the prior six-month period. InvestingPro additionally provides investors with a suite of 11 tailored recommendations for OLMA, covering areas such as its financial health and prospects for profitability.

In recent developments regarding Olema Pharmaceuticals, a number of investment firms have updated their evaluations and price targets for the stock. Piper Sandler has entered coverage of Olema Pharmaceuticals, assigning an Overweight rating and a price target of $40, citing the promising potential of palazestrant, a therapeutic candidate targeting estrogen receptor-positive/HER2-negative breast cancer. Similarly, UBS commenced coverage with a Buy recommendation and a more optimistic price target of $45, emphasizing Olema’s distinctive standing as a small to mid-cap biotech focused on a late-stage Phase III selective estrogen receptor degrader (SERD) indicated for metastatic disease.

Other investment banks have also adjusted their outlooks positively. H.C. Wainwright elevated its price target to $45 from $36 while sustaining a Buy rating, referencing recently presented interim results from the Phase 3 lidERA trial discussed by Roche at the San Antonio Breast Cancer Symposium (SABCS). Goldman Sachs raised its price target to $38 from $26, attributing the upgrade to encouraging data from the same Roche study. Jefferies followed suit by boosting its price target to $43 from $30 and maintained a Buy stance, viewing the Roche trial results as validation for the SERD drug class, which encompasses Olema’s palazestrant.

These series of price target enhancements and favorable analyst commentary collectively signal growing confidence in Olema Pharmaceuticals’ potential to make significant advances in the breast cancer treatment landscape.

Risks

  • Olema Pharmaceuticals' stock has displayed significant volatility with a 479.07% return over six months, indicating potential price risk for investors.
  • The clinical success and commercial viability of Olema’s palazestrant and other SERD drugs remain contingent on ongoing and future trial results, as outlined by recent updates from Roche’s Phase 3 lidERA trial.
  • Market valuation above Fair Value may expose the stock to potential corrections, representing a risk for shareholders amid the sector's competitive biotech landscape.

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